3,4-Diethoxybenzene-1-carbothioamide → HCID 19041058, compound

HRID 1683786Notes

Reaction equation

HRID 1683786 reaction equation
[CH3:1][N:2]([CH3:18])[C:3]1[CH:8]=[C:7]([C:9]([O:11]CC)=[O:10])[N:6]=[C:5]([C:14](=O)[CH2:15]Br)[CH:4]=1.[CH2:19]([O:21][C:22]1[CH:23]=[C:24]([CH:28]=[CH:29][C:30]=1[O:31][CH2:32][CH3:33])[C:25]([NH2:27])=[S:26])[CH3:20]>>[CH2:19]([O:21][C:22]1[CH:23]=[C:24]([C:25]2[S:26][CH:15]=[C:14]([C:5]3[CH:4]=[C:3]([N:2]([CH3:1])[CH3:18])[CH:8]=[C:7]([C:9]([OH:11])=[O:10])[N:6]=3)[N:27]=2)[CH:28]=[CH:29][C:30]=1[O:31][CH2:32][CH3:33])[CH3:20]

Participants

3

Reactant 2

HCID 77452503,4-Diethoxybenzene-1-carbothioamideHCID 22067663HCID 22067663, compound

Product 1

HCID 19041058HCID 19041058, compound

Procedure

A reaction was conducted in the same manner as in Example 1, by using 4-dimethylamino-6-ethoxycarbonyl-2-(α--bromoacetyl)pyridine and 3,4-diethoxythiobenzamide. Then, hydrolysis was conducted in the same manner as in Example 2 to obtain 2-(3,4-diethoxyphenyl)-4-(4-dimethylamino-6-carboxy-2-pyridyl)thiazole.

Workup

  1. customThen, hydrolysis

Sources & evidence

ORD record
ord-1c01359905aa4b9ca7ddd8cbd56c620a
Source dataset
uspto-grants-1997_06
Patent number
US05639770

Reaction notes

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