HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Chloropyrimidine → HCID 19040774, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Chloropyrimidine | HCID 74404 | — |
| Reactant | Sodium Acetate | HCID 517045 | — |
| Reactant | 3-(2-DIMETHYLAMINO-ETHYL)-1H-INDOL-5-YLAMINE | HCID 11820211 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | HCID 19040774 | HCID 19040774 | 11% |
Reaction Steps
5-Amino-3-(2-dimethylaminoethyl)-1H-indole and 2-chloropyrimidine were used, Sodium acetate was used as base, acetic acid was used as solvent, and the reaction was heated at reflux for 12 hours. Column chromatography afforded the title compound (11%) as a yellow solid: 13C NMR (CD3OD) δ162.6, 159.2, 135.4, 132.2, 128.9, 124.0, 118.6, 113.7, 112.6, 112.4, 112.3, 61.3, 45.4, 24.3; HRMS calculated for C16H19N5 281.1642, found 281.1660. Anal. calcd for C16H19N5.0.5C2H4O2 [acetic acid]: C, 65.62; H, 6.80; N, 22.51. Found: C, 65.74; H, 6.68; N, 22.60.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05639752 |
| Source dataset | uspto-grants-1997_06 |
| ORD ID | ord-e765168daf994707b1971e3c7e1f2a93 |
| Source note | uspto-grants-1997_06 |