Trifluoroacetic acid → HCID 86749475, compound

Participants

Reaction Steps

To a solution of (3E,4E)-1-t-butoxycarbonylmethyl -3-benzylidene-4-(3,4,5-trimethoxybenzylidene)-2,5-pyrrolidinedione (3.5 g) obtained in Example 42 in dichloromethane (40 ml) is added trifluoroacetic acid (10 ml) at room temperature, and the mixture is allowed to stand for 4 hours. The mixture is evaporated under reduced pressure to remove the solvent, and to the residue is added trichloromethane. The mixture is washed, dried, and evaporated to remove the solvent. The resulting residue is crystallized from diethyl ether to give (3 E,4E)- 1 -carboxymethyl-3-benzylidene-4-(3,4,5-trimethoxybenzylidene) -2,5-pyrrolidinedione (2.5 g) as yellow prisms.

Provenance & Evidence