Sodium Hydroxide → HCID 19041666, compound

Participants

Reaction Steps

To a solution of ester from Step 11 (150 mg, 0.33 mmol) in 5 mL MeOH was added 2N NaOH (0.5 mL, 1 mmol). The reaction mixture was heated to reflux for 3 h then cooled and partitioned between 1N HCl and ethyl acetate. The organic layer was washed with brine, dried over Na2SO4 and evaporated. The residue was filtered through a plug of silicic acid and the solid obtained was swished in (1: 1 ) Et2O-hexane. Collection of the solid provided 110 mg of the title compound.

Provenance & Evidence