HCID 54543898, compound → HCID 19041655, compound

Participants

Reaction Steps

To the ester (520 mg, 1.17 mmol) of Step 3 dissolved in a THF/MeOH mixture (4.0 mL/20.0 mL) was added an excess of Mg and a few drops of 1,2-dibromoethane. The reduction was initated by heating at reflux. After standing for a few hours at room temperature, the reaction mixture was quenched by the addition of a 25% aqueous NH4OAc solution, extracted with EtOAc, dried over MgSO4 and evaporated in vacuo. The desired reduced product was purified by flash chromatography (25% EtOAc in hexane) to provide 170 mg of an oil.

Provenance & Evidence