5-Methoxy-2-methylindole → HCID 19041729, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 2-methyl-5-methoxy indole (1.01 g, 6.2 mmol), methyl 2-(bromomethyl)benzoate (1.60 g, 6.9 mmol) and silver (I) oxide (1.59 g, 6.9 mmol) in dioxane (8 mL) was heated to 50° C. for 20 h. The mixture was cooled, diluted with EtOAc and filtered thorugh celite. The filtrate was concentrated and the resulting residue was chromatographed to give 406 mg of the title compound.

Provenance & Evidence