Sodium Hydroxide → HCID 19041680, compound

Participants

Reaction Steps

To a solution of the product of Step 2 (300 mg, 0.62 mmol) in THF (2 mL) and MeOH (4 mL) was added NaOH (3N, 0.62 mL). The mixture was refluxed for 2.5 h and then cooled to r.t. Acidification with 1N HCl followed by extraction with EtOAc gave 148 mg of the title compound after evaporation of solvent. Anal. calcd. for C25H22NO3Br --H2O: C, 63.43, H, 4.90; N, 2.96; found: C, 63.77; H, 4.89; N, 3.12.

Provenance & Evidence