HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → HCID 19041650, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Oxalyl chloride | HCID 65578 | — |
| Reactant | 4-(1-(4-Bromobenzyl)-5-methoxy-2-methyl-1H-indol-3-yl)-3-methylbutanoic acid | HCID 9867333 | — |
| Solvent | Benzene | HCID 241 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 19041650 | HCID 19041650 | — |
Reaction Steps
To the acid of Example 7, Step 6, (600 mg, 1.39 mmol) in benzene (10.0 mL) was added at 0° C. DMF (50 mL) and oxalyl chloride. After a period of 30 min at 0° /C., THF (10.0 mL) was added to the resulting mixture and ammonia gas was bubbled until saturation. The mixture was stirred for 4 h at r.t. The reaction was poured over water, extracted with EtOAc, dried over Na2SO4, evaporated in vacuo and filtered over silica gel (50% EtOAc in THF) to provide the desired amide (530 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05639780 |
| Source dataset | uspto-grants-1997_06 |
| ORD ID | ord-123036ca79af4ffc871ceb1d5ffa7a11 |
| Source note | uspto-grants-1997_06 |