Hydrochloric Acid → HCID 19622754, compound

Participants

Reaction Conditions

Reaction Steps

Syringaldehyde (1.0 g, 5.49 mmole), 2-iodo-1-ethanol (1.90 g, 10.98 mmole) and potassium carbonate (1.90 g, 13.77 mmole) are added to 15 ml dry DMF and stirred for 24 hours at 80° C. under an argon atmosphere. The reaction mixture is added to 100 ml H2O and acidified with 10% HCl. The product is extracted into CHCl3, dried over MgSO4, and concentrated to an oil in vacuo. The remaining oil is purified by flash column chromatography using 1:1 hex/ethyl acetate as eluent (1.009 g, 81%).

Provenance & Evidence