HCID 19042271, compound → HCID 19042264, compound

Participants

Reaction Steps

A mixture of nitro compound 15 (1.0 g, 3.1 mmol) in ethyl acetate (20 mL) and Pt/C (200 mg) was stirred for 2 hrs under H2 (1 atm). The reaction mixture was filtered through Celite and concentrated under reduced pressure. The crude product was recrystalized with benzene providing amino ethane 16 as a white solid (709 mg, 78%), m.p. 134°-136° C. 1H NMR (CDCl3): 2.12 (s, 3H), 4.29 (s, 4H) (s, 4H), 6.4-6.3 (m, 1H), 6.46 (dd, J=12.5, 2.5 Hz, 1H), 6.7-6.6 (m, 2H), 6.85 (dd, J=9, 9 Hz, 1H), 8.30 (dd, J=9, 6 Hz, 1H).

Provenance & Evidence