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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1684358Generated: October 31, 2026

6,7-Dimethoxy-1,2,3,4-Tetrahydroisoquinoline → alpha-(3,4-dimethoxyphenyl)-3,4-dihydro-6,7-dimethoxy-alpha-((4-methylphenyl)thio)-2(1H)-isoquinolineheptanenitrile

https://huagongshe.com/reaction/1684358

Reaction equation

Participants

RoleNameHCIDCharge
Reactant6,7-Dimethoxy-1,2,3,4-TetrahydroisoquinolineHCID 15623—
Reactantalpha-(5-Chloropentyl)-3,4-dimethoxy-alpha-[(4-methylphenyl)-thio]benzeneacetonitrileHCID 10573255—
Productalpha-(3,4-dimethoxyphenyl)-3,4-dihydro-6,7-dimethoxy-alpha-((4-methylphenyl)thio)-2(1H)-isoquinolineheptanenitrileHCID 982928156.9%

Reaction Steps

The procedure of Example 3 is repeated using 4.65 g of α-(5-chloropentyl)-3,4-dimethoxy-α-[(4-methylphenyl)thio]benzeneacetonitrile and 4.25 g of 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline. This affords 3.67 g of the desired product as a light brown gum.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS05639887
Source datasetuspto-grants-1997_06
ORD IDord-1bbee75fc5ba4050847bf6baf660f19d
Source noteuspto-grants-1997_06