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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1684371Generated: October 31, 2026

6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride → 2-[6-(3,4-Dimethoxyphenyl)-6-[(4-methylphenyl)thio]hexyl]-1,2,3,4-tetrahydro-6,7-dimethoxyisoquinoline

https://huagongshe.com/reaction/1684371

Reaction equation

Participants

RoleNameHCIDCharge
Reactant6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline hydrochlorideHCID 6456035—
Reactant4-[6-Bromo-1-[(4-methylphenyl)thio]hexyl]-1,2-dimethoxybenzeneHCID 10812203—
Product2-[6-(3,4-Dimethoxyphenyl)-6-[(4-methylphenyl)thio]hexyl]-1,2,3,4-tetrahydro-6,7-dimethoxyisoquinolineHCID 1076868659.6%

Reaction Steps

The procedure of Example 39 is repeated using 2.12 g of 4-[6-Bromo-1-[(4-methylphenyl)thio]hexyl]-1,2-dimethoxybenzene and 2.3 g of 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride. This affords 1.6 g of the desired product as a light yellow oil.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS05639887
Source datasetuspto-grants-1997_06
ORD IDord-7419b73c6f9a4743a538281d58c5ecee
Source noteuspto-grants-1997_06