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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1684379Generated: November 2, 2026

6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride → alpha-(Cyclohexylthio)-alpha-(3,4-dimethoxyphenyl)-3,4-dihydro6,7-dimethoxy-2(1H)-isoquinolineheptane nitrile

https://huagongshe.com/reaction/1684379

Reaction equation

Participants

RoleNameHCIDCharge
Reactant6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline hydrochlorideHCID 6456035—
Reactantalpha-(5-Chloropentyl)-alpha-(cyclohexylthio)-3,4-dimethoxy-benzeneacetonitrileHCID 11795020—
Productalpha-(Cyclohexylthio)-alpha-(3,4-dimethoxyphenyl)-3,4-dihydro6,7-dimethoxy-2(1H)-isoquinolineheptane nitrileHCID 1053074766.3%

Reaction Steps

The procedure of Example 3 is repeated using 2.7 g of α-(5-chloropentyl)-α-(cyclohexylthio)-3,4-dimethoxybenzeneacetonitrile and 2.53 g of 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride. This affords 2.5g of the desired product as a light yellow oil.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS05639887
Source datasetuspto-grants-1997_06
ORD IDord-4ac5615c12d541e19e3c35a1ded9f893
Source noteuspto-grants-1997_06