HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,2,3,4-Tetrahydro-6,7,8-trimethoxyisoquinoline → 2-[7-(3,4-Dimethoxyphenyl)-7-[(4-methylphenyl)thio]heptyl]-1,2,3,4-tetrahydro-6,7,8-trimethoxyisoquinoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,2,3,4-Tetrahydro-6,7,8-trimethoxyisoquinoline | HCID 192723 | — |
| Reactant | 4-[6-Bromo-1-[(4-methylphenyl)thio]heptyl]-1,2-dimethoxybenzene | HCID 19042093 | — |
| Reactant | 5,6-Dimethoxyisoindoline | HCID 20074351 | — |
| Product | 2-[7-(3,4-Dimethoxyphenyl)-7-[(4-methylphenyl)thio]heptyl]-1,2,3,4-tetrahydro-6,7,8-trimethoxyisoquinoline | HCID 10650882 | 65.7% |
Reaction Steps
The procedure of Example 49 is repeated using 5.31 g 4-[6-bromo-1-[(4-methylphenyl)thio]heptyl]-1,2-dimethoxybenzene, 3.29 g of 5,6-dimethoxyisoindoline and 2.65 g of 6,7,8-trimethoxy-1,2,3,4-tetrahydroisoquinoline. This affords 4.52 g of the desired product as a yellow oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05639887 |
| Source dataset | uspto-grants-1997_06 |
| ORD ID | ord-2caf9163a5a9445eb7b72994b6edb205 |
| Source note | uspto-grants-1997_06 |