2,6-Dihydroxybenzoic Acid → HCID 178524829, compound

Participants

Reaction Conditions

Reaction Steps

A 3-liter thermostatic reactor fitted with a pneumatic stirrer, a bottom valve, temperature probes, a reflux condenser and a heating system is employed for this synthesis. 900 ml of distilled water and 15.4 g of γ-resorcylic acid, that is 0.1 mole of acid, are placed in the reactor. The heterogeneous mixture is heated to 50° C. with stirring and then 31 g of bismuth oxide, that is 0.1 gram-atom of bismuth, are added portionwise over approximately 15 minutes. The suspension thus obtained is heated to 80° C. After approximately 30 minutes approximately 1500 ml of distilled water are added to permit better stirring of the suspension and the suspension is then left stirred for approximately 5 hours at 80° C. The mixture is then filtered hot and the cake obtained is then washed with 500 ml of ethanol. The product is next vacuum-dried at 60° C. over calcium chloride. At the end of reaction 24 g of bismuth γ-resorcylate are recovered.

Provenance & Evidence