4-Ethyl-4-p-tolyl-4-silacyclohexanone → 4-(4-(4-Fluorophenyl)phenyl)-1-ethyl-1-p-tolyl-1-silacyclohexane

Participants

Reaction Steps

Using the same method as Example 14, 23.2 g of 4-ethyl-4-p-tolyl-4-silacyclohexanone was reacted with 4-(4-fluorophenyl)phenyl magnesium bromide; the alcohol generated was treated with a dehydration reaction followed by catalytic reduction to obtain 4-(4-(4-fluorophenyl)phenyl)-1-ethyl-1-p-tolyl-1-silacyclohexane; this was then reacted with iodine monochloride; and then the product was reduced using lithium aluminum hydride to obtain 2.12 g (yield 71%) of the target product.

Provenance & Evidence