HCID 137327395, compound → HCID 178447779, compound

Participants

Reaction Steps

3.0 g (20 mmols) of n-pentyl bromide was dropped in a mixture of 0.5 g of magnesium (21 mmols) and 50 ml of tetrahydrofuran (hereinafter referred to simply as THF) to obtain a Grignard reagent. Subsequently, the solution was dropped in 50 ml of a THF solution of 5.5 g (20 mmols) of 4-(3,4-difluorophenyloxymethyl)-1-chloro-1-silacyclohexane to obtain a crude product. This product was found to be a mixture of trans and cis isomers with respect to the silacyclohexane ring. The product was after-treated by a usual manner and isolated through column chromatography to obtain 5.6 g (yield: 89%) of the intended trans isomer product The results of measurement of a phase transition temperature and the IR analysis are shown below.

Provenance & Evidence