Benzyl Bromide → HCID 15341579, compound

Participants

Reaction Conditions

Reaction Steps

To a mixture of 10 g (0.043 mol) of trans-3-ethenyl-7-hydroxy-3,3a,4,5-tetrahydro-1H-oxazolo[3,4-a]quinolin-1-one (obtained in Step 2 of Example 1) and 12 g (0.086 mol) of potassium carbonate in 250 ml of acetonitrile and 50 ml of dimethylformamide are added 8.9 g (0.052 mol) of benzyl bromide. The mixture is stirred at 80° C. for 1 h then filtered while hot and washed with acetonitrile, and the filtrate is evaporated to dryness under reduced pressure. The residue is taken up in ethyl acetate and washed several times with water, and the organic phase is then dried over sodium sulphate and concentrated under reduced pressure. After recrystallization from diisopropyl ether, 12.8 g of product are obtained.

Provenance & Evidence