Ethyl chloroformate → HCID 19039847, compound

Participants

Reaction Steps

To a solution of 69.3 g (0,313 mol) of (±)-6-methoxy-2-methoxycarbonyl-1,2,3,4-tetrahydroquinoline and 39 ml (0.407 mol) of ethyl chloroformate in 1400 ml of dichloromethane are added 85 g (0.63 mol) of potassium carbonate, and the mixture is heated at reflux for 18 h. The mixture is filtered, the filtrate is concentrated under reduced pressure and the residue is chromatographed on a column of silica, with a 3/7 mixture of ethyl acetate and cyclohexane. 80.4 g of product are obtained in the form of an oil.

Provenance & Evidence