Ammonia → HCID 19039846, compound

HRID 1684541Notes

Reaction equation

HRID 1684541 reaction equation
C[O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[N:9]1[C:13](=[O:16])[O:14][CH2:15][CH:8]1[CH2:7][CH2:6]2.B(Br)(Br)Br.N>ClCCl>[OH:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[N:9]1[C:13](=[O:16])[O:14][CH2:15][CH:8]1[CH2:7][CH2:6]2

Participants

5

Reactant 3

HCID 222AmmoniaHCID 25134Boron tribromideHCID 19039850HCID 19039850, compound

Product 1

HCID 19039846HCID 19039846, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of 4.6 g (21 mmol) of 7-methoxy-3,3a,4,5-tetrahydro-1H-oxazolo[3,4-a]quinolin-1-one in 50 ml of dichloromethane are added dropwise, at 0° C., 4.0 ml (42 mmol) of boron tribromide. After one hour, the medium is hydrolyzed by addition of aqueous ammonia to the point of neutrality. The precipitate formed is then filtered off and dried under vacuum.

Workup

  1. customThe precipitate formed
  2. filtrationis then filtered off
  3. customdried under vacuum

Sources & evidence

ORD record
ord-6b4f3198e4674e519ea3bf2e9052109e
Source dataset
uspto-grants-1997_06
Patent number
US05641785

Reaction notes

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