HCID 19039853, compound → HCID 22874130, compound

HRID 1684543Notes

Reaction equation

HRID 1684543 reaction equation
C([CH:3]1[CH2:12][CH2:11][C:10]2[C:5](=[CH:6][CH:7]=[C:8]([O:13][CH3:14])[CH:9]=2)[N:4]1[C:15]([O:17][CH2:18][CH3:19])=[O:16])=O.C[Mg]Br>C(OCC)C>[CH3:14][O:13][C:8]1[CH:9]=[C:10]2[C:5](=[CH:6][CH:7]=1)[N:4]1[C:15](=[O:16])[O:17][C@@H:18]([CH3:19])[C@@H:3]1[CH2:12][CH2:11]2

Participants

4

Reactant 2

HCID 19039853HCID 19039853, compoundHCID 178418573HCID 178418573, compound

Product 1

HCID 22874130HCID 22874130, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Conditions

Temperature
0 °C

Procedure

Starting with a solution of ethyl 2-formyl-6-methoxy-1,2,3,4-tetrahydroquinoline-1-carboxylate in diethyl ether, cooled to 0° C., and methylmagnesium bromide, these reactants being treated under similar conditions to those of Step 1 of Example 1, the cis derivative,

Sources & evidence

ORD record
ord-e465867b9cac411897c05ac2a6e9fab2
Source dataset
uspto-grants-1997_06
Patent number
US05641785

Reaction notes

Loading…