HRID1684588

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：COc1ccc(-c2c(C(=O)c3ccccc3)c(CBr)nc3cc(OC)c(OC)cc23)cc1OC

HCID19039911

未命名化合物

HCID178480602

未命名化合物

PRODUCTS

生成物

结构：COc1ccc(-c2c(C(=O)c3ccccc3)c(CSc3nccn3C)nc3cc(OC)c(OC)cc23)cc1OC

HCID19039912

未命名化合物

PROCEDURE

实验过程

According to the same manner as that described in Example 4, 3-benzoyl-2-bromomethyl-4-(3,4-dimethoxyphenyl)-6,7-dimethoxyquinoline was reacted with 2-mercapto-1-methylimidazole to give 3-benzoyl-4-(3,4-dimethoxyphenyl)-6,7-dimethoxy-2-[(1-methylimidazol-2-yl)thiomethyl]quinoline. This compound was recrystallized from ethanol to give colorless prisms. mp. 185°-186° C.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-e4db555da326426c9678e7ef9094a9a8
来源数据集: uspto-grants-1997_06
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05641788
来源说明: uspto-grants-1997_06

反应 SMILES

[C:1]([C:9]1[C:10]([CH2:33]Br)=[N:11][C:12]2[C:17]([C:18]=1[C:19]1[CH:24]=[CH:23][C:22]([O:25][CH3:26])=[C:21]([O:27][CH3:28])[CH:20]=1)=[CH:16][C:15]([O:29][CH3:30])=[C:14]([O:31][CH3:32])[CH:13]=2)(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[SH:35][C:36]1[N:37]([CH3:41])[CH:38]=[CH:39][N:40]=1>>[C:1]([C:9]1[C:10]([CH2:33][S:35][C:36]2[N:37]([CH3:41])[CH:38]=[CH:39][N:40]=2)=[N:11][C:12]2[C:17]([C:18]=1[C:19]1[CH:24]=[CH:23][C:22]([O:25][CH3:26])=[C:21]([O:27][CH3:28])[CH:20]=1)=[CH:16][C:15]([O:29][CH3:30])=[C:14]([O:31][CH3:32])[CH:13]=2)(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1