HCID 54445383, compound → HCID 15379686, compound

HRID 1684599Notes

Reaction equation

HRID 1684599 reaction equation
[N:1]12[CH2:8][CH2:7][CH:4]([CH2:5][CH2:6]1)[C:3](=[C:9]([C:15]#[N:16])[C:10]([O:12][CH2:13][CH3:14])=[O:11])[CH2:2]2.[H][H]>C(O)C.[Pd]>[N:1]12[CH2:8][CH2:7][CH:4]([CH2:5][CH2:6]1)[CH:3]([CH:9]([C:15]#[N:16])[C:10]([O:12][CH2:13][CH3:14])=[O:11])[CH2:2]2

Participants

5

Reactant 2

HCID 54445383HCID 54445383, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 15379686HCID 15379686, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

A solution of ethyl (1-azabicyclo[2.2.2]octan-3-ylidene)cyanoacetate (73 g, 0.33 mol) in absolute ethanol (1l) was treated with 10% palladium on charcoal (10 g) and hydrogen in a parr shaker at 20 psi for 5 h. Filtration and evaporation gave the wanted product in 68 g yield.

Workup

  1. filtrationFiltration and evaporation
  2. customgave the wanted product in 68 g
  3. customyield

Sources & evidence

ORD record
ord-a71e1e6fb97d434aaffb9f6c667ffe73
Source dataset
uspto-grants-1997_06
Patent number
US05641791

Reaction notes

Loading…