Water → HCID 53736551, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 20.0 g of aldehyde from Example 17 Part A, 8.29 g of semicarbazide hydrochloride, 8.14 g of NaOAc and 150 mL of H2O was heated for 0.75 hours at 100° C. with occasional swirling. The heterogenous mixture was diluted with 150 mL of MeOH and allowed to stand at 25° C. for 64 hours. The solid was filtered and washed with H2O, refluxed with 500 mL of MeOH and filtered hot leaving 21.3 g of 4-(2-(2-phenyl-4-oxazolyl)ethoxy)benzaldehyde semicarbazone (89%, m.p. 221°-226° C.).

Provenance & Evidence