Dimethylformamide → HCID 19040023, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 11.9 g of semicarbazide from Example 17 Part C, 8.10 g of carbonyldiimidazole, 0.5 mL of triethylamine and 400 mL of anhydrous DMF was stirred at 25° C. for 4 days, diluted with 1 L of H2O and filtered. The filtrate was evaporated. The residue was treated with 100 mL of MeOH and the solid was filtered and dried to give 3.43 g of 1-[(4-(2-(2-phenyl-4-oxazolyl)ethoxy)phenyl)methyl]1,2,4-triazolidin-3,5-dione (27%. mp 223.5°-230° C.).

Provenance & Evidence