1,2-Dimethoxyethane → 2-[5-(4-Chloro-2-formyl-phenyl)-1H-imidazol-2-yl]-pyrrolidine-1-carboxylic acid tert-butyl ester

HRID 168466Notes

Reaction equation

HRID 168466 reaction equation
[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH:9]([c:13]2[nH:14][c:15]([Br:18])[cH:16][n:17]2)[CH2:10][CH2:11][CH2:12]1.[CH3:108][O:109][CH2:110][CH2:111][O:112][CH3:113].[Cl:19][c:20]1[cH:21][c:22]([CH:29]=[O:30])[c:23]([B:26]([OH:27])[OH:28])[cH:24][cH:25]1.[cH:31]1[cH:32][cH:33][c:34]([P:35]([Pd:36]([P:37]([c:38]2[cH:39][cH:40][cH:41][cH:42][cH:43]2)([c:44]2[cH:45][cH:46][cH:47][cH:48][cH:49]2)[c:50]2[cH:51][cH:52][cH:53][cH:54][cH:55]2)([P:56]([c:57]2[cH:58][cH:59][cH:60][cH:61][cH:62]2)([c:63]2[cH:64][cH:65][cH:66][cH:67][cH:68]2)[c:69]2[cH:70][cH:71][cH:72][cH:73][cH:74]2)[P:75]([c:76]2[cH:77][cH:78][cH:79][cH:80][cH:81]2)([c:82]2[cH:83][cH:84][cH:85][cH:86][cH:87]2)[c:88]2[cH:89][cH:90][cH:91][cH:92][cH:93]2)([c:94]2[cH:95][cH:96][cH:97][cH:98][cH:99]2)[c:100]2[cH:101][cH:102][cH:103][cH:104][cH:105]2)[cH:106][cH:107]1>>[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH:9]([c:13]2[nH:14][c:15](-[c:23]3[c:22]([CH:29]=[O:30])[cH:21][c:20]([Cl:19])[cH:25][cH:24]3)[cH:16][n:17]2)[CH2:10][CH2:11][CH2:12]1

Participants

5

Reactant 4

HCID 80711,2-DimethoxyethaneHCID 237304254-Chloro-2-formylphenylboronic Acid (contains varying amounts of Anhydride)HCID 56605248tert-Butyl 2-(5-bromo-1H-imidazol-2-yl)pyrrolidine-1-carboxylateHCID 178420554HCID 178420554, compound

Product 1

HCID 723382662-[5-(4-Chloro-2-formyl-phenyl)-1H-imidazol-2-yl]-pyrrolidine-1-carboxylic acid tert-butyl ester

Sources & evidence

ORD record
ord-43bb154b8cde4ceb9ce514bd374b0088
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

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