反应详情

温度

50 °C

1N sodium hydroxide solution (11.1 ml) is added to a solution of 2-(3-methoxypropoxy)-benzoic acid ethyl ester (2.4 g) in ethanol (20 ml) and water (10 ml), and the reaction mixture is stirred at 50° C. for 7 hours. The mixture is concentrated and the acidified aqueous phase is extracted with dichloremethane (3×40 ml). The organic phase is washed with saturated sodium chloride solution, dried over magnesium sulfate and concentrated. 2-(3-Methoxypropoxy)-benzoic acid, Rf (hexane-ethyl acetate-glacial acetic acid 1:2:0.1)=0.43, is obtained in the form of a yellowish oil.

1. concentrationThe mixture is concentrated
2. extractionthe acidified aqueous phase is extracted with dichloremethane (3×40 ml)
3. washThe organic phase is washed with saturated sodium chloride solution
4. dry with materialdried over magnesium sulfate
5. concentrationconcentrated