Hydrochloric Acid → HCID 69646475, compound

Participants

Reaction Steps

A solution of (2S,4S,5S,7R)-N-{4-(tert-butoxycarbonyl)amino-5-hydroxy-2-isopropyl-7-[(2-morpholin-4-ylethyl)-carbamoyl]-octyl}-2-(3-methoxypropoxy)-benzamide (105 mg) in 4N hydrochloric acid solution in dioxane (4 ml) is stirred at 0° C. for one hour. The reaction mixture is then lyophilised. (2S,4S,5S,7R)-N-[4-Amino-5-hydroxy-2-methyl-7-[(2-morpholin-4-ylethyl)-carbamoyl]-octyl}-2-(3-methoxypropoxy)-benzamide dihydrochloride is obtained in the form of a beige powder: Rf (dichloromethane-methanol 8:2)=0.28. HPLC Rt =7.73 min. MS(FAB) m/e 551 (M+ +1).

Provenance & Evidence