tert-butyl N-tert-butoxycarbonyl-4,4-dimethylproline → (S)-4,4-dimethylpyrrolidine-2-carboxylic acid

HRID 1684808Notes

Reaction equation

HRID 1684808 reaction equation
C([C@@:5]1([C:19]([OH:21])=[O:20])[CH2:9][C:8]([CH3:11])([CH3:10])[CH2:7][N:6]1C(OC(C)(C)C)=O)(C)(C)C>ClCCl>[CH3:10][C:8]1([CH3:11])[CH2:7][NH:6][C@H:5]([C:19]([OH:21])=[O:20])[CH2:9]1

Participants

3

Reactant 1

HCID 67158944tert-butyl N-tert-butoxycarbonyl-4,4-dimethylproline

Product 1

HCID 46907953(S)-4,4-dimethylpyrrolidine-2-carboxylic acid

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A solution of tert-butyl N-tert-butoxycarbonyl-4,4-dimethylproline in dichloromethane (5 mL) and trifluoroacetic (5 mL) was stirred at room temperature for five hours. The solution was concentrated, dried under high vacuum and taken to the next step without further purification.

Workup

  1. concentrationThe solution was concentrated
  2. customdried under high vacuum
  3. customtaken to the next step without further purification

Sources & evidence

ORD record
ord-56238b79bf8e4876a8c816dff94dc2f6
Source dataset
uspto-grants-2012_04
Patent number
USRE043298E1

Reaction notes

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