Methanol → HCID 21015967, compound

HRID 1684809Notes

Reaction equation

HRID 1684809 reaction equation
[N:1]1(C(OC(C)(C)C)=O)[CH2:8][C:7]([CH3:10])([CH3:9])[CH2:6][C@H:2]1[C:3]([OH:5])=[O:4].S(Cl)([Cl:20])=O.[CH3:22]O>>[ClH:20].[CH3:22][O:5][C:3](=[O:4])[C@@H:2]1[CH2:6][C:7]([CH3:10])([CH3:9])[CH2:8][NH:1]1

Participants

4

Reactant 3

HCID 887MethanolHCID 24386Thionyl ChlorideHCID 250673061-(tert-Butoxycarbonyl)-4,4-dimethyl-L-proline

Product 1

HCID 21015967HCID 21015967, compound

Procedure

To a solution of Boc-Pro(4,4-diMe)-OH (0.5 g, 2.06 mmol) in anhydrous methanol (8 ml) was added dropwise thionylchloride (448 g, 6.18 mmol) and the reaction was stirred for six hours at room temperature. The reaction mixture was concentrated to an amorphous solid (377 mg, 95%).

Workup

  1. concentrationThe reaction mixture was concentrated to an amorphous solid (377 mg, 95%)

Sources & evidence

ORD record
ord-696188d0a22a43afa651f35351c4c027
Source dataset
uspto-grants-2012_04
Patent number
USRE043298E1

Reaction notes

Loading…