HCID 21015972, compound → HCID 67159338, compound

HRID 1684810Notes

Reaction equation

HRID 1684810 reaction equation
[C:1]([O:5][C:6]([N:8]1[CH2:15][C:14]([CH2:17][CH:18]=[CH2:19])([CH3:16])[CH2:13][C@H:9]1[C:10]([OH:12])=[O:11])=[O:7])([CH3:4])([CH3:3])[CH3:2]>CO.[Pd]>[C:1]([O:5][C:6]([N:8]1[CH2:15][C:14]([CH2:17][CH2:18][CH3:19])([CH3:16])[CH2:13][C@H:9]1[C:10]([OH:12])=[O:11])=[O:7])([CH3:4])([CH3:3])[CH3:2]

Participants

4

Reactant 1

HCID 21015972HCID 21015972, compound

Product 1

HCID 67159338HCID 67159338, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

A solution of N-tertbutoxycarbonyl-4-allyl-4-methylproline (400 mg, 1.48 mmol) (see Example II Step 4) and 10% Pd on carbon (400 mg) in methanol (20 mL) was hydrogenated at 50 psi for 4 hours. The mixture was filtered and concentrated.

Workup

  1. filtrationThe mixture was filtered
  2. concentrationconcentrated

Sources & evidence

ORD record
ord-90b328bac4b043ef9af773bd138bac58
Source dataset
uspto-grants-2012_04
Patent number
USRE043298E1

Reaction notes

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