HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → n-Heptyl N-[chloro(4-chlorophenoxy)phosphoryl]-L-alaninate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | L-alanine n-heptyl ester hydrochloride | HCID 44225940 | — |
| Reactant | Para-chlorophenyl dichlorodiphosphate | HCID 86761540 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | n-Heptyl N-[chloro(4-chlorophenoxy)phosphoryl]-L-alaninate | HCID 59157900 | — |
Reaction Steps
Following the procedure described for Step 1 of Example 1, treatment of a DCM (0.098 M) solution of para-chlorophenyl dichlorodiphosphate with L-alanine n-heptyl ester hydrochloride (1.0 eq.) and Et3N (2.0 eq.) provided the title compound as a colourless oil as a 1:1 mixture of diastereomers.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08148349B2 |
| Source dataset | uspto-grants-2012_04 |
| ORD ID | ord-8230ae283f454ef5add18456644ec707 |
| Source note | uspto-grants-2012_04 |