Phenyl isocyanate → (+/-) N-(4-Oxo-2-pyridin-4-yl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-9-yl)-N'-phenylurea

HRID 1684898Notes

Reaction equation

[NH2:1][CH:2]1[C:7]2=[N:8][C:9]([C:13]3[CH:18]=[CH:17][N:16]=[CH:15][CH:14]=3)=[CH:10][C:11](=[O:12])[N:6]2[CH2:5][CH2:4][CH2:3]1.[C:19]1([N:25]=[C:26]=[O:27])[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1>ClCCl>[O:12]=[C:11]1[N:6]2[CH2:5][CH2:4][CH2:3][CH:2]([NH:1][C:26]([NH:25][C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=3)=[O:27])[C:7]2=[N:8][C:9]([C:13]2[CH:18]=[CH:17][N:16]=[CH:15][CH:14]=2)=[CH:10]1

Participants

Conditions

Temperature: 10 °C

Procedure

To a solution of 0.07 g (0.29 mmol) of (+/−) 9-amino-2-pyridin-4-yl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one dissolved in 1 mL of dichloromethane at 10° C. was added 0.034 g (0.29 mmol) of phenylisocyanate dissolved in 1 mL at 10° C. The resulting mixture was stirred at 10° C. for 30 min. The mixture was stirred at room temperature for 1 h.

Workup

dissolutiondissolved in 1 mL at 10° C
stirringThe mixture was stirred at room temperature for 1 h.

Sources & evidence

ORD record: ord-e6cb31e0ca664583b1fb28ba58f984a3
Source dataset: uspto-grants-2012_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08148364B2

Reaction notes

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