HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl 3-(4-pyridyl)-3-oxopropionate → (+/-) 2-(4-Oxo-2-pyrimidin-4-yl-4,6,7,8,9,10-hexahydropyrimido[1,2-a]azepin-10-yl)-1H-isoindole-1,3(2H)-dione
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl 3-(4-pyridyl)-3-oxopropionate | HCID 2735202 | — |
| Reactant | Ethyl 3-oxo-3-(pyrimidin-4-yl)propanoate | HCID 11961458 | — |
| Reactant | HCID 178479134 | HCID 178479134 | — |
| Product | (+/-) 2-(4-Oxo-2-pyrimidin-4-yl-4,6,7,8,9,10-hexahydropyrimido[1,2-a]azepin-10-yl)-1H-isoindole-1,3(2H)-dione | HCID 67265833 | — |
Reaction Steps
By analogy with the method described in example 1 (step 1.3), using ethyl 3-(4-pyrimidinyl)-3-oxopropionate (prepared by analogy to the method described in patent DE 2705582) in place of ethyl 3-(pyridin-4-yl)-3-oxopropionate and using 2-(2-iminoazepan-3-yl)-1H-isoindole-1,3(2H)-dione hydrochloride (1:1), the compound was obtained as a white powder.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08148364B2 |
| Source dataset | uspto-grants-2012_04 |
| ORD ID | ord-8569fe79029f48e5bd28453cc4a310a0 |
| Source note | uspto-grants-2012_04 |