N-(2-Oxo-3-piperidyl)phthalimide → 2-(2-Methoxy-3-methyl-3,4,5,6-tetrahydropyridin-3-yl)-1H-isoindole-1,3(2H)-dione

HRID 1684902Notes

Reaction equation

HRID 1684902 reaction equation
[CH3:1][C:2]1([N:9]2[C:17](=[O:18])[C:16]3[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=3)[C:10]2=[O:19])[CH2:7][CH2:6][CH2:5][NH:4][C:3]1=[O:8].[C:20]1(=O)N(C2CCCNC2=O)C(=O)C2=CC=CC=C12>>[CH3:20][O:8][C:3]1[C:2]([N:9]2[C:17](=[O:18])[C:16]3[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=3)[C:10]2=[O:19])([CH3:1])[CH2:7][CH2:6][CH2:5][N:4]=1

Participants

3

Reactant 2

HCID 135339N-(2-Oxo-3-piperidyl)phthalimideHCID 104452231H-Isoindole-1,3(2H)-dione, 2-(3-methyl-2-oxo-3-piperidinyl)-

Product 1

HCID 672654652-(2-Methoxy-3-methyl-3,4,5,6-tetrahydropyridin-3-yl)-1H-isoindole-1,3(2H)-dione

Procedure

By analogy with the method described in example 1 (step 1.1), using 2-(3-methyl-2-oxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione (prepared by analogy to the method described in Liebigs Annalen der Chemie (1987), (7), 647-8. Archiv der Pharmazie (Weinheim, Germany) (1989), 322(8), 499-505, (Heterocycles (1996), 42(2), 537-42, Enantiomer (2001), 6(5), 275-279, Synthesis (1991), (5), 417-20)) in place of 3-phtalimidopiperidin-2-one, the compound was obtained as a yellow oil.

Workup

  1. customprepared by analogy to the method
  2. customthe compound was obtained as a yellow oil

Sources & evidence

ORD record
ord-2924854368c146589128c5f1292d811c
Source dataset
uspto-grants-2012_04
Patent number
US08148364B2

Reaction notes

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