Ethyl 3-(4-pyridyl)-3-oxopropionate → (+/-) 2-(4-Oxo-2-pyridin-4-yl-4,6,7,8,9,10-hexahydropyrimido[1,2-a]azepin-10-yl)-1H-isoindole-1,3(2H)-dione

HRID 1684905Notes

Reaction equation

HRID 1684905 reaction equation
[N:1]1[CH:6]=[CH:5][C:4]([C:7](=O)[CH2:8][C:9]([O:11]CC)=O)=[CH:3][CH:2]=1.Cl.[NH:16]=[C:17]1[CH:23]([N:24]2[C:32](=[O:33])[C:31]3[C:26](=[CH:27][CH:28]=[CH:29][CH:30]=3)[C:25]2=[O:34])[CH2:22][CH2:21][CH2:20][CH2:19][NH:18]1>>[O:11]=[C:9]1[N:18]2[CH2:19][CH2:20][CH2:21][CH2:22][CH:23]([N:24]3[C:32](=[O:33])[C:31]4[C:26](=[CH:27][CH:28]=[CH:29][CH:30]=4)[C:25]3=[O:34])[C:17]2=[N:16][C:7]([C:4]2[CH:3]=[CH:2][N:1]=[CH:6][CH:5]=2)=[CH:8]1

Participants

3

Reactant 2

HCID 2735202Ethyl 3-(4-pyridyl)-3-oxopropionateHCID 178479134HCID 178479134, compound

Product 1

HCID 67265732(+/-) 2-(4-Oxo-2-pyridin-4-yl-4,6,7,8,9,10-hexahydropyrimido[1,2-a]azepin-10-yl)-1H-isoindole-1,3(2H)-dione

Procedure

By analogy with the method described in example 1 (step 1.3), using ethyl 3-(pyridin-4-yl)-3-oxopropionate and using 2-(2-iminoazepan-3-yl)-1H-isoindole-1,3(2H)-dione hydrochloride (1:1), the compound was obtained as a white powder.

Workup

  1. customthe compound was obtained as a white powder

Sources & evidence

ORD record
ord-22fb13d23f75458f9f6aa3921e358bbb
Source dataset
uspto-grants-2012_04
Patent number
US08148364B2

Reaction notes

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