反应详情

162 mg of sodium borohydride are added portionwise to 150 mg of 3-[2-(4-chlorophenyl)imidazo[1,2-a]pyridin-6-yl]-2-fluorobenzaldehyde dissolved in 20 ml of methanol. The mixture is subsequently stirred at ambient temperature for 2 hours and then the solvent is evaporated under reduced pressure. The residue is taken up between water and dichloromethane and the organic phase is separated, dried over sodium sulphate and evaporated under reduced pressure. The residue is purified by chromatography on silica gel, elution being carried out with a dichloromethane/methanol 98/02 mixture. 87 mg of compound are obtained.

1. customthe solvent is evaporated under reduced pressure
2. customthe organic phase is separated
3. dry with materialdried over sodium sulphate
4. customevaporated under reduced pressure
5. customThe residue is purified by chromatography on silica gel, elution