Sodium borohydride → HCID 44231857, compound

Participants

Reaction Steps

154 mg of sodium borohydride are added portionwise to 150 mg of 3-[2-(4-chlorophenyl)imidazo[1,2-a]pyridin-6-yl]-2,6-difluorobenzaldehyde dissolved in 20 ml of methanol. The mixture is subsequently stirred at ambient temperature for 3 hours and then the solvent is evaporated under reduced pressure. The residue is taken up between water and dichloromethane and then the organic phase is separated, dried over sodium sulphate and evaporated under reduced pressure. The residue is triturated from pentane, collected by filtration and then dried in an oven under reduced pressure. 67 mg of compound are obtained.

Provenance & Evidence