反应详情

2.00 g of 3-bromo-2-fluorobenzaldehyde are dissolved in 98 ml of methanol; 560 mg of sodium borohydride are added portionwise thereto. The mixture is stirred at ambient temperature for 2 hours and then the solvent is evaporated under reduced pressure. The residue is taken up between water and ethyl acetate and the organic phase is separated, dried and concentrated under reduced pressure. The residue is purified by chromatography on silica gel, elution being carried out with a dichloromethane/methanol mixture. 1.56 g of compound are obtained.

1. customthe solvent is evaporated under reduced pressure
2. customthe organic phase is separated
3. customdried
4. concentrationconcentrated under reduced pressure
5. customThe residue is purified by chromatography on silica gel, elution