5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-amine → HCID 58189653, compound

HRID 1684921Notes

Reaction equation

HRID 1684921 reaction equation
[CH3:1][C:2]1([CH3:16])[C:6]([CH3:8])([CH3:7])[O:5][B:4]([C:9]2[CH:10]=[CH:11][C:12]([NH2:15])=[N:13][CH:14]=2)[O:3]1.Br[CH2:18][C:19]([C:21]1[CH:26]=[CH:25][C:24]([F:27])=[CH:23][C:22]=1[F:28])=O>>[F:28][C:22]1[CH:23]=[C:24]([F:27])[CH:25]=[CH:26][C:21]=1[C:19]1[N:15]=[C:12]2[CH:11]=[CH:10][C:9]([B:4]3[O:3][C:2]([CH3:16])([CH3:1])[C:6]([CH3:7])([CH3:8])[O:5]3)=[CH:14][N:13]2[CH:18]=1

Participants

3

Reactant 2

HCID 27565555-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-amineHCID 27741852-Bromo-2',4'-difluoroacetophenone

Product 1

HCID 58189653HCID 58189653, compound

Procedure

By carrying out the procedure as in stage 4.1, starting from 4.76 g of 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-ylamine and 5.09 g of 2-bromo-1-(2,4-difluorophenyl)ethanone, 4.84 g of compound are obtained.

Workup

  1. customare obtained

Sources & evidence

ORD record
ord-4de7d3d52816494ca73f699c9a0c8f97
Source dataset
uspto-grants-2012_04
Patent number
US08148370B2

Reaction notes

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