HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cyclopropylacetylene → HCID 67263322, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cyclopropylacetylene | HCID 138823 | — |
| Reactant | Ethyl 6-amino-5-bromonicotinate | HCID 7210833 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | HCID 67263322 | HCID 67263322 | 78.2% |
Reaction Steps
Cyclopropyl acetylene (3 mmol) was reacted with ethyl 6-amino-5-bromonicotinate (245 mg, 1 mmol) as described in procedure A of Example 1. Ethyl 6-amino-5-(2-cyclopropylethynyl)nicotinate (180 mg) was obtained as a solid after silica gel column chromatography (EtOAc:hexanes, 1:1). LC/MS; (M+H)+=231.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08148361B2 |
| Source dataset | uspto-grants-2012_04 |
| ORD ID | ord-e4d0a526daf4477c859b730c446848bb |
| Source note | uspto-grants-2012_04 |