Butylamine → 2-Butylaminoadenine

HRID 1684963Notes

Reaction equation

HRID 1684963 reaction equation
Cl[C:2]1[N:10]=[C:9]2[C:5]([NH:6][CH:7]=[N:8]2)=[C:4]([NH2:11])[N:3]=1.[CH2:12]([NH2:16])[CH2:13][CH2:14][CH3:15]>>[CH2:12]([NH:16][C:2]1[N:10]=[C:9]2[C:5]([NH:6][CH:7]=[N:8]2)=[C:4]([NH2:11])[N:3]=1)[CH2:13][CH2:14][CH3:15]

Participants

3

Reactant 2

HCID 8007ButylamineHCID 949042-Chloroadenine

Product 1

HCID 34879632-ButylaminoadenineYield 30%

Procedure

2-Chloroadenine (6.0 g, 35.4 mmol) and n-butylamine (30 ml) were reacted in an autoclave (200 ml) at 130° C. for 150 hours. After the reaction mixture was concentrated under reduced pressure, the residue was poured into water to precipitate the solid. The precipitated solid was successively washed with methylene chloride and methanol to give the captioned compound (2.08 g, yield 30%) as a yellowish orange powdered solid.

Workup

  1. concentrationAfter the reaction mixture was concentrated under reduced pressure
  2. additionthe residue was poured into water
  3. customto precipitate the solid
  4. washThe precipitated solid was successively washed with methylene chloride and methanol

Sources & evidence

ORD record
ord-5120daebfcee4199a866e8c799b01124
Source dataset
uspto-grants-2012_04
Patent number
US08148371B2

Reaction notes

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