Isoamyl mercaptan → {4-[6-(3-Methylbutylsulfanyl)pyridazin-3-YL]piperazin-1-YL}-(2-trifluoromethyl-phenyl)methanone

Participants

Reaction Steps

Following the procedure set forth above in Example 6, only making variations using 3-methylbutane-1-thiol to replace 2-phenylethanethiol to react with [4-(6-chloropyridazin-3-yl)piperazin-1-yl]-(2-trifluoromethylphenyl)methanone, the title compound was obtained as a white solid (24.3 mg, 26.4% yield). 1H NMR (400 MHz, CDCl3) δ 8.04, 7.98, 6.99, 3.79, 3.56, 3.45-3.47, 3.40, 1.85-1.87, 1.52, 0.72-0.80, 0.46-0.48, 0.09-0.10.

Provenance & Evidence