HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1685009Generated: November 4, 2026
Ethyl 2-aminothiazole-4-carboxylate → Ethyl 2-(3-(3,4-dichlorobenzyl)ureido)thiazole-4-carboxylate
https://huagongshe.com/reaction/1685009
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ethyl 2-aminothiazole-4-carboxylate | HCID 73216 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | Isocyanate | HCID 105034 | — |
| Reactant | 1,2-Dichloro-4-(isocyanatomethyl)benzene | HCID 2733368 | — |
| Catalyst | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| Solvent | N-methyl-2-pyrrolidone | HCID 13387 | — |
| Product | Ethyl 2-(3-(3,4-dichlorobenzyl)ureido)thiazole-4-carboxylate | HCID 86622748 | — |
Reaction Steps
The commercial starting material ethyl 2-aminothiazole-4-carboxylate (2 mmol) was dissolved in NMP and DIEA (1 equivalent) was added followed by addition of the 3,4-dichloro-benzyl isocyanate (1 equivalent). Add 5% DMAP. Heat at 160° C. under microwave irradiation for 30 min Added additional isocyanate reagent (1.0 eq) and microwave for another 30 minutes at 160° C. to obtain ethyl 2-(3-(3,4-dichlorobenzyl)ureido)thiazole-4-carboxylate in >90% conversion.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08148380B2 |
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| Source dataset | uspto-grants-2012_04 |
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| ORD ID | ord-b8d44578a78149b5b2eac6302de7fe4c |
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| Source note | uspto-grants-2012_04 |
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