3-Fluorobenzyl isocyanate → HCID 86661280, compound

HRID 1685011Notes

Reaction equation

HRID 1685011 reaction equation
Cl[C:2]1[CH:3]=[C:4]([CH:19]=[CH:20][C:21]=1Cl)[CH2:5][NH:6][C:7]([NH:9][C:10]1[S:11][CH:12]=[C:13]([CH:15]([NH:17][CH3:18])[CH3:16])[N:14]=1)=[O:8].[F:23]C1C=C(C=CC=1)CN=C=O>>[F:23][C:2]1[CH:3]=[C:4]([CH:19]=[CH:20][CH:21]=1)[CH2:5][NH:6][C:7]([NH:9][C:10]1[S:11][CH:12]=[C:13]([CH:15]([NH:17][CH3:18])[CH3:16])[N:14]=1)=[O:8]

Participants

3

Reactant 2

HCID 6434993-Fluorobenzyl isocyanateHCID 86661278HCID 86661278, compound

Product 1

HCID 86661280HCID 86661280, compound

Procedure

The 1-(3-fluorobenzyl)-3-(4-(1-(methylamino)ethyl)thiazol-2-yl)urea was prepared following the same procedure described for Intermediate 10a using 3-fluoro-benzyl isocyanate in step one.

Sources & evidence

ORD record
ord-1c0b96f0d9d945f8b14a2e550d0989cc
Source dataset
uspto-grants-2012_04
Patent number
US08148380B2

Reaction notes

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