HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methylamine → HCID 58055069, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methylamine | HCID 6329 | — |
| Reactant | Sodium cyanoborohydride | HCID 5003444 | — |
| Reactant | HCID 86661281 | HCID 86661281 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 58055069 | HCID 58055069 | — |
Reaction Steps
Ethyl 2-(2-(3-(3,4-dichlorobenzyl)ureido)thiazol-4-yl)-2-oxoacetate (800 mg) was dissolved in 2 M methylamine in tetrahydrofuran (20 ml) and NaCNBH3 (2.2 eq.) was added and stirred at room temperature overnight. The title compound was purified by column using 0-10% gradient of 7 N ammonia/MeOH and DCM.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08148380B2 |
| Source dataset | uspto-grants-2012_04 |
| ORD ID | ord-a6e8f31948144050865470e790e4b130 |
| Source note | uspto-grants-2012_04 |