HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1685017Generated: October 30, 2026
Triacetoxyperiodinane → 1-(3-Fluorobenzyl)-3-(4-formylthiazol-2-yl)urea
https://huagongshe.com/reaction/1685017
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Triacetoxyperiodinane | HCID 159087 | — |
| Reactant | (3-Fluoro-benzyl)-3-(4-hydroxymethyl-thiazol-2-yl)-urea | HCID 86661282 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 1-(3-Fluorobenzyl)-3-(4-formylthiazol-2-yl)urea | HCID 58055046 | — |
Reaction Steps
The 1-(3-fluorobenzyl)-3-(4-(hydroxymethyl)thiazol-2-yl) urea is taken up in DCM and cooled to 0° C. and Dess-Martin oxidant (1.1 equiv) was added. Stirred at ambient temperature for 1 hour. Washed with dilute Na2SO3. Removed solvent in vacuo to give 1-(3-fluorobenzyl)-3-(4-formylthiazol-2-yl)urea (used directly in next step).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08148380B2 |
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| Source dataset | uspto-grants-2012_04 |
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| ORD ID | ord-ab8c7923fc5d4b48b1dc6e7832c8f4e3 |
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| Source note | uspto-grants-2012_04 |
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