HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Fluorobenzyl isocyanate → 1-(4-(Chloromethyl)thiazol-2-yl)-1-(2,4-dimethoxybenzyl)-3-(3-fluorobenzyl)urea
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Fluorobenzyl isocyanate | HCID 643499 | — |
| Reactant | 4-(chloromethyl)-N-(2,4-dimethoxybenzyl)thiazol-2-amine | HCID 86661289 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 1-(4-(Chloromethyl)thiazol-2-yl)-1-(2,4-dimethoxybenzyl)-3-(3-fluorobenzyl)urea | HCID 58055094 | — |
Reaction Steps
The 4-(chloromethyl)-N-(2,4-dimethoxybenzyl)thiazol-2-amine was dissolved in DCM (50 ml) and 3-fluorobenzylisocyanate (1.2 eq.) was added and stirred overnight. The mixture was concentrated and the residue was purified on a column using 0-100% gradient of EtOAc and hexanes to give the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08148380B2 |
| Source dataset | uspto-grants-2012_04 |
| ORD ID | ord-9b435ebd3bb5445783fc6b251a3bdf06 |
| Source note | uspto-grants-2012_04 |