HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methylamine → 1-[4-(Cyano-methylamino-methyl)-thiazol-2-yl]-3-(3-fluoro-benzyl)-urea
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methylamine | HCID 6329 | — |
| Reactant | Trimethylsilyl cyanide | HCID 82115 | — |
| Reactant | 1-(3-Fluorobenzyl)-3-(4-formylthiazol-2-yl)urea | HCID 58055046 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 1-[4-(Cyano-methylamino-methyl)-thiazol-2-yl]-3-(3-fluoro-benzyl)-urea | HCID 86661304 | — |
Reaction Steps
Trimethylsilyl cyanide (161 μL) was added to a solution of 1-(3-fluoro-benzyl)-3-(4-formyl-thiazol-2-yl)-urea (409 mg) and MeNH2 (8 M, 0.4 mL) in (EtOH 10 mL) at 0° C. The reaction mixture was stirred at room temperature for 2 hours. The additional of 170 μL of trimethylsilyl cyanide was added to convert all starting material into the product. The product was purified by aqueous work-up and chromatography.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08148380B2 |
| Source dataset | uspto-grants-2012_04 |
| ORD ID | ord-91009f2ed39b4e6da17847a017def14b |
| Source note | uspto-grants-2012_04 |