Methanol → HCID 131729537, compound

HRID 1685070Notes

Reaction equation

[C:1]([SiH2:5][O:6][C:7]([C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1)([C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1)[CH:8]1[O:12][C@@H:11]([C:13]#N)[CH2:10][CH2:9]1)([CH3:4])([CH3:3])[CH3:2].[CH3:27][O-:28].[Na+].C[OH:31]>>[CH3:27][O:28][C:13]([C@H:11]1[CH2:10][CH2:9][CH:8]([C:7]([C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=2)([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)[O:6][SiH2:5][C:1]([CH3:4])([CH3:3])[CH3:2])[O:12]1)=[O:31]

Participants

Reactant 3

HCID 887Methanol

HCID 10942334Sodium Methoxide

HCID 131729538HCID 131729538, compound

Product 1

HCID 131729537HCID 131729537, compound

Procedure

(R)-5-(tert-Butyl-diphenyl-silanyloxymethyl)-tetrahydro-furan-2-carbonitrile was treated with sodium methoxide in MeOH to afford (R)-5-(tert-Butyl-diphenyl-silanyloxymethyl)-tetrahydro-furan-2-carboxylic acid methyl ester.

Sources & evidence

ORD record: ord-d3411d37829d472eab431e297713df0e
Source dataset: uspto-grants-2012_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08148380B2

Reaction notes

Loading…